منابع مشابه
Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides.
The gp41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) mediates membrane fusion during viral entry. The crystal structure of the HIV-1 gp41 ectodomain core in its proposed fusion-active state is a six-helix bundle. Here we have reconstituted the core of the SIV gp41 ectodomain with two synthetic peptides called SIV N36 and SIV C34, which fo...
متن کاملMembrane-Anchored HIV-1 N-Heptad Repeat Peptides Are Highly Potent Cell Fusion Inhibitors via an Altered Mode of Action
Peptide inhibitors derived from HIV-gp41 envelope protein play a pivotal role in deciphering the molecular mechanism of HIV-cell fusion. According to accepted models, N-heptad repeat (NHR) peptides can bind two targets in an intermediate fusion conformation, thereby inhibiting progression of the fusion process. In both cases the orientation towards the endogenous intermediate conformation shoul...
متن کاملPoster Session: Physiology, Endocrinology, and Reproduction
post inoculation. Across all isolates there was a linear improvement in performance and decrease in coccidiosis lesions. Within all categories there were not significant differences between the NMI and N125 except for E. acervulina lesion scores (NMI 0.0 and N125 0.4). All other treatments and categories were significantly different. Feed conversions were NMU 1.447, NMI 2.594, N36 1.956, N72 1....
متن کاملCore Structure of gp41 from the HIV Envelope Glycoprotein
The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell receptors, while gp41 mediates fusion between viral and cellular membranes. Previous studies identified an alpha-helical domain within gp41 composed of a trimer of two interacting peptides. The crystal structure of this comple...
متن کاملReport on the 1st Indian Cancer Congress 2013
The 1st Indian Cancer Congress (Delhi, 21-24th Nov) has been a reminder that the world of cancer is not all about the ASCOs and the ECCOs. What made this conference arguably more impactful and important globally than most others, was its relevance not just for India but also for many other emerging and low-income economies. Most cancer patients will live and die far away from high-income system...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EccoS – Revista Científica
سال: 2015
ISSN: 1983-9278,1517-1949
DOI: 10.5585/eccos.n36.5950